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Evaluation of liver protective activity of Moringa oleifera bark extract in paracetamol induced hepatotoxicity in rats capillaries and arteries generic 30 mg procardia fast delivery. Jahir Alam 2 1 2 * Corresponding author: malsI lubijaR hs ed algnaB cardiovascular or aerobic exercise buy procardia without prescription,2431-akahD heart disease heart attack discount procardia 30mg with mastercard,ravaS cardiovascular disease victoria generic procardia 30 mg without prescription,ytisrevinU raga nrignahaJ,ycamrahP fo t nemtrapeD. Abstract Background: Moringa oleifera has been used in folk medicine to alleviate several diseases. In the present study, ethanolic extract of Moringa oleifera bark has been investigated to study its potential on paracetamol induced hepatotoxicity on model rats. Acute hepatotoxicity was induced by paracetamol (600 mg/kg body weight) administered once daily for one week whereas the extract of investigated plant was given orally throughout the whole experiment at 250 and 500mg/kg body weight. Silymarin (100mg/kg body weight) was given orally as standard hepatoprotective drug. Conclusion: the biochemical parameters provide evidence that the ethanolic extract of of Moringa oleifera bark has shown hepatoprotective activity. Key words: Moringa oleifera, hepatoprotective activity, paracetamol induced hepatotoxicity, liver enzymes. Introduction Liver is the major organ which plays a key roles in processing critical biochemical and physiological phenomena including metabolism and Detoxification of endogen and exogenous compounds, such as drugs and xenobiotics, homeostasis, growth, energy and nutrient supply [1, 2] Hepatic injury could be occurred by hepatotoxic agents including drugs, alcohol and viral infections. Due to the fact, a huge number of medicinal plants have been trialed to figure out regenerative and hepatoprotective activity [3] Approximately 160 phytochemical constituents originated from 101 plants have been reported to be potentially hepatoprotective. Bangladesh, a country of great biodiversity of medicinal plants having a long history of use of traditional medicine along with phytotherapeutic potential mainly from native source. As a result, research in medicinal plants have been a huge area of discovering of promising lead compounds in Bangladesh. The plant is indigenous and abundantly seen in India, Pakistan, Bangladesh and Afghanistan. Then the solvent washing the constituents of powder was collected in a container, dried with a rotary evaporator under reduced pressure to get viscous substance. Finally a solid mass was obtained and preserved in a petridis in the refrigerator. Experimental animals For the experiment, Sprague Dawley rats of either sex, weighing between 150-200g, were collected from the animal research lab in the Department of Pharmacy, Jahangirnagar University, Savar, Dhaka. The animals were acclimatized to laboratory condition for one week prior to experiments. All protocols for animal experiment were approved by the institutional animal ethical committee. Toxicity studies Toxicity studies of the extracts were carried out in Swiss Albino mice of either sex weighing between 20 and 25 g. Experimental design for the assessment of liver functions Animal study was performed at Pharmacology Laboratory, Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342. After sacrifice, blood samples from each group of rats were collected and the serum was separated by centrifugation. Serum samples were subjected to liver function tests of enzymes such as glutamate pyruvate transaminase bioRxiv preprint doi: doi. The results obtained were compared with the vehicle treated paracetamol control group. Therefore, macromolecules like enzymes will leak from the damaged tissues into the bloodstream, [34] and a study of these enzyme activities in plasma has been found to be of great importance in the assessment of liver damage [35]. An abnormal increase in the levels of bilirubin in plasma indicates hepatobiliary disease and severe disturbance of hepatocellular function [38]. Plasma proteins are mainly produced by the liver, the principle exception being immunoglobulins. Severe liver damage decreases the production of various proteins resulting in reduced serum levels of total protein, albumin, and/ or globulin [39, 40]. The results indicate that protein level was slightly increased at 250 mg/kg and 500mg/kg dose which was insignificant.

Syndromes

  • Sudden collapse (cardiac arrest)
  • Abdominal pain -- severe
  • Clean the area thoroughly with soap and water. Also wash your hands thoroughly.
  • Seizure medicines such as phenytoin
  • Do you frequently swim or participate in water sports? Do you change your clothes soon after such activities?
  • Trembling
  • Several types of Hib vaccine are available for children ages 2 months and older.
  • BUN
  • Side effects of medications used to control pain

This systematic review concurs with and updates the conclusions drawn by the 2015 Committee cardiovascular disease prevalence buy generic procardia 30 mg on-line. Most articles did not specify or differentiate between the types of carbohydrate replacing saturated fat (e cardiovascular disease description generic procardia 30 mg otc. However cardiovascular system vocabulary words discount procardia uk, among the few articles that differentiated plant and animal sources cardiovascular system function and structure order procardia, monounsaturated fat from plants tended to be associated with lower risk. Chapter 9: Dietary Fats and Seafood assessed omega-3 polyunsaturated fat and some assessed omega-6 polyunsaturated fat. Other important characteristics of participants in some included articles did not mirror those of the U. Some studies did not use validated dietary assessment methods or were limited by high attrition. This Committee conducted a systematic review of more recent studies, including those examining the effects of dietary saturated fat intake and its replacement by other types of fats, specifically polyunsaturated fat, monounsaturated fat, and carbohydrates as they relate to intermediate (e. Chapter 9: Dietary Fats and Seafood Studies in Children Dietary fat contributes energy (calories) to the diet of growing children and is especially important in infants and young children because they are not able to consume very large quantities of food at one time. Therefore, the higher caloric density of fat (9 calories/gram, compared to protein and carbs, which have 4 calories/gram) is important because it helps to meet the energy demands of the rapid growth that occurs during this life stage. Fatty acids also play a major role in brain development and other important physiological functions. Before the age of 12 months, approximately 40 percent of energy intake comes from dietary fats, with a reduction to about 30 percent from age 24 months throughout preschool years (see Part D. Additionally, the Committee found moderate evidence suggesting that diets higher in polyunsaturated fat during childhood result in lower levels of total blood cholesterol throughout childhood, particularly in boys. For participating infants who were consuming human milk or formula, the saturated fat reduction applied only to complementary foods and beverages. The study also did not find significant influences on blood pressure, but sodium intake was not addressed in this study. This review found insufficient evidence to draw conclusions about the relationship between dietary fat during childhood and blood pressure throughout childhood. Studies varied considerably in their design and age-ranges and whether salt intake, a known mediator of blood pressure, was assessed. All associations between monounsaturated fat intake, including those that modeled replacement, and blood lipids were non-significant. Dietary studies in children are difficult to conduct not only due to ethical concerns, but also because of issues with compliance, follow-up, accuracy in assessing dietary adherence and confounders. Despite these challenges, dietary intervention studies in children are of critical Scientific Report of the 2020 Dietary Guidelines Advisory Committee 20 Part D. Chapter 9: Dietary Fats and Seafood importance, particularly given the growing evidence that poor nutrition in childhood heavily contributes to poor health outcomes-both chronic and acute-and subsequently poorer quality of life in adulthood. Because there is no biological requirement for saturated fat or dietary cholesterol, diets lower in these components that also contain foods consistent with the recommended dietary patterns, can be applied to children age 2 years and older. This approach appears to be safe and promotes dietary adherence useful for establishing healthy lifelong eating behaviors and potential cardiovascular benefits across the life course. In articles that examined replacement of saturated fat with monounsaturated fat or polyunsaturated fat, the intervention Scientific Report of the 2020 Dietary Guidelines Advisory Committee 21 Part D. The new evidence the Committee reviewed remains inadequate to differentiate among types and food sources of carbohydrates and their impact on blood lipids. The mechanism by which different types of carbohydrates influence blood lipids is not yet fully understood and evidence reviewed by the Committee did not provide insight into this relationship. Chapter 9: Dietary Fats and Seafood atherogenic risk and response to therapeutic intervention. However, the Committee recognizes the importance of and growing body of research on the specific fatty acids, food matrix and sources of fats, explicitly saturated fat. Results from these studies were inconsistent and resulted in inconclusive findings. Chapter 9: Dietary Fats and Seafood sources of monounsaturated fat in the typical American diet.

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Changes in intake of plant-based diets and weight change: results from 3 prospective cohort studies coronary heart attacks discount 30mg procardia visa. Healthful dietary patterns and long-term weight change among women with a history of gestational diabetes mellitus cardiovascular system embryology cheap 30 mg procardia with amex. Improving adherence to healthy dietary patterns cardiovascular disease knowledge test buy procardia 30 mg online, genetic risk capillaries in lungs generic procardia 30mg otc, and long term weight gain: gene-diet interaction analysis in two prospective cohort studies. Longitudinal 10-year changes in dietary intake and associations with cardio-metabolic risk factors in the Northern Sweden Health and Disease Study. High-carbohydrate versus high-fat diets: effect on body composition in trained cyclists. Alteration of dietary fat intake to prevent weight gain: Jayhawk Observed Eating Trial. Diets with high or low protein content and glycemic index for weight-loss maintenance. A 3 years follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain. Diet quality and six-year risk of overweight and obesity among mid-age Australian women who were initially in the healthy weight range. Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference. Longitudinal association between animal and vegetable protein intake and obesity among men in the United States: the Chicago Western Electric Study. Dietary quality predicts adult weight gain: findings from the Framingham Offspring Study. Diet quality indices and risk of type 2 diabetes mellitus: the Singapore Chinese Health Study. Plant versus animal based diets and insulin resistance, prediabetes and type 2 diabetes: the Rotterdam Study. Everything in moderation-dietary diversity and quality, central obesity and risk of diabetes. Adherence to a food group-based dietary guideline and incidence of prediabetes and type 2 diabetes. Strong adherence to dietary and lifestyle recommendations is associated with decreased type 2 diabetes risk in the AusDiab cohort study. A priori-defined diet quality indexes and risk of type 2 diabetes: the Multiethnic Cohort. Dietary patterns derived by reduced rank regression are inversely associated with type 2 diabetes risk across 5 ethnic groups in the multiethnic cohort. A priori-defined diet quality indices, biomarkers and risk for type 2 diabetes in five ethnic groups: the Multiethnic Cohort. Generalizability of a diabetes-associated country-specific exploratory dietary pattern is feasible across european populations. Adherence to a healthy Nordic food index is associated with a lower risk of type-2 diabetes-The Danish Diet, Cancer and Health Cohort Study. A diabetes-related dietary pattern is associated with incident diabetes in obese men in the Korean Genome Epidemiology Study. A high diet quality based on dietary recommendations is not associated with lower incidence of type 2 diabetes in the Malmo Diet and Cancer cohort. A high-fat, high-glycaemic index, low-fibre dietary pattern is prospectively associated with type 2 diabetes in a British birth cohort. A Mediterranean diet rich in extra-virgin olive oil Is associated with a reduced prevalence of nonalcoholic fatty liver disease in older individuals at high cardiovascular risk. Prevention of diabetes with Mediterranean diets: a subgroup analysis of a randomized trial. Dietary patterns related to triglyceride and high-density lipoprotein cholesterol and the incidence of type 2 diabetes in Korean men and women. Adherence to predefined dietary patterns and risk of developing type 2 diabetes in the Canadian adult population. Low carbohydrate-diet scores and long-term risk of type 2 diabetes among women with a history of gestational diabetes mellitus: a prospective cohort study. Associations of specific dietary protein with longitudinal insulin resistance, prediabetes and type 2 diabetes: the Rotterdam Study. High intakes of protein and processed meat associate with increased incidence of type 2 diabetes.

Overall cardiovascular system vocabulary safe procardia 30mg, people who drink and smoke are 15 times more likely to develop cancers of the mouth and throat than nondrinkers and nonsmokers cardiovascular definition cheap procardia online master card. In addition capillaries in the body purchase procardia 30 mg without a prescription, the study concluded that cancer risk increases no matter how little or what kind of alcohol a woman drinks blood vessels kidneys buy 30 mg procardia with amex. Even one drink a day can raise risk, and it continues to rise with each additional drink. While men did not participate in this study, the researchers believe this risk is likely similar for men. This study also attributes about 11 percent of all breast cancer cases to alcohol. That means that of the 250,000 breast cancer cases diagnosed in the United States in 2008, about 27,000 may stem from alcohol. We know that metabolizing, or breaking down, alcohol results in harmful toxins in the body. It also causes cells to grow too quickly, which makes conditions ripe for genetic changes and mistakes. Cirrhosis results when too much scar tissue builds up within the liver and leaves it unable to perform its vital functions. Alcohol can increase the amounts of some hormones in the body, including estrogen. Finally, genetics may play a role in preventing some heavy drinkers from developing cancer. A European research team examined 9,000 people with similar lifestyle habits to determine why some of them developed mouth and throat cancers, and some did not. Of the participants who were heavy drinkers, those who did not develop cancers had a particular genetic alteration that enabled them to break down alcohol about 100 times faster than in those without it. The study suggested that this gene is the reason why some people are less likely to develop cancer in response to heavy drinking. A recent Canadian report analyzed studies from 1966 through 2006 and concluded that risk reduction is possible, specifically for head and neck cancers. The study found that as people abstained from drinking, their risk for developing cancer plunged. After 20 years of abstinence, former drinkers had the same risk for head and neck cancers as people who never drank. Luckily, our immune system is designed to protect our bodies from the scores of foreign substances that can make us sick. Drinking too much alcohol weakens the immune system, making your body a much easier target for disease. Understanding the effect alcohol can have on your immune system can inform the decisions you make about drinking alcohol. If foreign substances somehow make it through these barriers, your immune system kicks into gear with two defensive systems: innate and adaptive. The innate system exists in your body before you are exposed to foreign substances like bacteria, viruses, fungi, or parasites. These substances, which are called antigens, can invade your body and make you sick. Your skin and the mucous that lines your respiratory and gastrointestinal tracts help block bacteria from entering or staying in 20 blood cells that detect and destroy cells infected with cancer or viruses. Cytokines trigger inflammatory responses, like dilating blood vessels and increasing blood flow to the affected area. These are proteins that target specific antigens and then remember how to combat the antigen. Chronic alcohol use reduces the ability of white blood cells to effectively engulf and swallow harmful bacteria. Excessive drinking also disrupts the production of cytokines, causing your body to either produce too much or not enough of these chemical messengers. An abundance of cytokines can damage your tissues, whereas a lack of cytokines leaves you open to infection.

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References:

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  • https://www.askjpc.org/wsco/wsc/wsc14/WSCProceedings2014-2015.pdf
  • https://www.modahealth.com/pdfs/med_criteria/Pembrolizumab.pdf
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  • https://clu-in.org/download/ert/2030-R00.pdf
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